P226 Interpretation of spirometry parameters in adult patients with cystic fibrosis in North Macedonia

Assessment of lung function, the flow in large, medium and small airways through analysis functional diagnostics-spirometry its parameters. We analyzed data from hospital records for 2022year, 25adult CF (cystic fibrosis) patients aged 18–45 were included, 14 men(56%), 11 women (44%). Sporometric parameters monitored: FVC(vital capacity), FEV1(forced expiratory volume 1 second), FEF1/FVC (Tiffno), MEF25–75%(forced at 25–75% vital capacity). From microbiological analyses-sputum chronic bacterial isolates In 5 (20%) normal pulmonary function FEV1, FVC>80%, Tiffno>70%). Type ventilatory insufficiency: combined type (FEV1, FVC, Tiffno<70–80%) 10(40%) patients, obstructive (FVC>80%, 6(24%), restrictive (FVC, FEV1<80%, Tiffno >70%) 4(16%) patients. Degree severity according to FEV1: Mild (FEV1>80%), 6 (24%), moderate(FEV1 = 50–79%) 9(36%) severe (FEV1 30–49%), 9(36%), very (FEV1<30%), patient (4%). The (MEF25–75%) is regulated, over 65%, 3 (12%), while it reduced 22 (88%). sputum microbiology, Pseudomonas aeruginosa(PsA) 11(44%), MRSA (Methicillin-resistant Staphylococcus aureus) 3(12%), Both bacteria 2(8%) aureus(SA) 2(8%), SA PsA 4 pac (16%) Candida spp (12%). Spirometry as a diagnostic particular importance assessment function. These mostly have insufficiency moderate degree, with significant involvement them.